Glucosatrol® - Advanced Glucose Disposal Agent

Glucosatrol® is the most advanced nutrient partitioning complex available on the market with 14 thoroughly researched ingredients.

What is Glucosatrol? What are Glucose Disposal Agents?

Glucose Disposal Agents (GDA) are supplements that are used to help control blood sugar, promote fat loss, help with storage of carbohydrates into the muscle cells instead of fat cells. They are often used to help offset a high carbohydrate meal that would otherwise promote fat gain. 

The basis for GDA supplement use is to help prevent insulin from sending glucose to be stored as fat and instead send it to muscles to be used for muscle protein synthesis. GDA's can also suppress appetite, increase metabolism, and lower cholesterol (while lowering triglycerides) as well as promote fat loss.

As previously mentioned, Glucose Disposal's are known to:

• Stimulate glycogen storage in Muscles ✝
• Support Healthy Insulin Utilization ✝
• Promote Fat loss ✝
• Support Healthy Glucose Metabolism ✝
• Promote Muscle Fullness & Vascularity ✝
• Ideal for Fasting & Ketogenic Diets ✝
• Support Healthy liver function.✝
• Support Healthy antioxidant activity.✝

• DESCRIPTION
• DIRECTIONS
• SUPPLEMENT FACTS
• INGREDIENTS
• WARNINGS & PRECAUTIONS
• REFERENCES

• In fitness and supplement communities, Glucose Disposal Agents are often referred to and used as "carb blockers" or "cheat meal defense". While these are not the reason GDA's were created, there are plenty of people who find they work great just for those very things. But GDA's are so much more than helping you rebound quicker from a cheat meal.
  
  GDA's contain a wide assortment of compounds that support glucose disposal. GDA's not only help regulate blood sugar levels and insulin release, but they also optimize nutrient partitioning (how your body stores nutrients).
  
  Many prescription meds often used in the treatment of type 2 diabetes have glucose disposal actions, such as: Metformin, Glipizide, Glyburide, etc. But of course most drugs come with side effects.
  
  Glucosatrol® contains an extensive list of ingredients that support glucose disposal. Not only do these ingredients promote healthy blood sugar levels and insulin release, but they also optimize nutrient partitioning (what becomes of the calories that enter your body in food, how your body stores these nutrients).
  
  So Glucosatrol is not just a powerful Glucose Disposal Agent and Nutrient Partitioner, we formulated Glucosatrol to be an overall health and wellness promoting product. This is the reason Glucosatrol is currently the #1 rated and selling Glucose Disposal Agent!
  

  
  

• Suggested Use: Take 6 capsules (1 serving) 10-15 minutes before your highest carbohydrate-containing meal. Can also take a second dose prior to your workout or prior to your pre-workout meal.

  For those on a Ketogenic Diet, in addition to a pre-meal dosage before an unplanned "cheat meal" or a carbohydrate-heavy planned "carb up" meal, users often take 1/2 to one full serving 2-3 times a day to help lower blood glucose and to help speed up re-entry into ketosis ✝
  
  For general health and well being: take 3 caps, 2 to 3 times a day preferably before a meal. 
  
  Stacks well with Betadrine ECA or Keto Lean.
  

   

• Supplement Facts:

  * Agmatine Sulfate - 750mg
  * Berberine HCL - 500mg
  * Bitter Melon Extract (std. 10% Momordica Charantia) - 500mg
  * Cinnamon Bark Extract - 500mg
  * Gymnema Sylvestre (Std to min. 25% gymnemic acids) - 500mg
  * Green Coffee Bean Extract (50% Chlorogenic Acid) - 500mg
  * Banaba Extract (Std. for Corosolic Acid) - 300mg
  * Olive Leaf Extract (20% Oleuropein) - 250mg
  * Alpha Lipoic Acid - 200mg
  * Gynostemma Pentaphyllum Extract (Std. to 98% Gypenosides) - 200mg
  * Vanadyl Sulfate - 15mg
  * Bioperine - 5mg
  * Vitamin B6 (as Pyridoxine HCL) - 5mg
  * Chromium Picolinate - 200mcg

• Read more about the full ingredient profile below:

  Chromium Picolinate
  
  Chromium has been around for decades and was a no-brainer to add it to this formula. Chromium is a trace element and after decades of research, researchers discovered that chromium helps the body to maintain a safe blood sugar level by boosting the signaling activity of insulin once insulin binds to cells. This signaling activity helps move glucose from the blood into the cells, thereby lowering the amount of sugar in the blood.
  
  Chromium is one of the most well known and common ingredient in a glucose disposal product with years of studies showing its ability to lower fasting blood glucose (1). Chromium Picolinate has been shown to reduce insulin resistance and to help reduce the risk of cardiovascular disease and type 2 diabetes. (1a)

  Agmatine Sulfate

  Agmatine Sulfate is another impressive and potent ingredient that in addition to its ability to prevent the breakdown of nitric oxide (more nitric oxide means better pump in the gym) it can reduce blood sugar AND improves the body's ability to push glucose into the muscle cell (where we want it) an not towards fat cells! Agmatine has also been shown to improve insulin sensitivity and has been shown to elevate the synthesis and tissue level of cAMP., thereby mimicking the effects of caloric restriction.(2,3,4,5)
  
  Before we move on to the rest of these impressive ingredients, lets first talk about Adenosine Monophosphate-Activated Protein Kinase (AMPK). 

  On top of these wide array of benefits, we formulated Glucosatrol® with a few very special and powerful ingredients that in addition to their anti-inflammatory and blood sugar controlling benefits, these compounds also stimulate Adenosine Monophosphate-Activated Protein Kinase (AMPK).
  
  Increased AMPK activity supports better insulin sensitivity and glucose uptake into muscle cells, while also reducing the amount of glucose generated by the liver.

  Increased AMPK activation is associated with longer lifespan and better health; AMPK causes a biochemical cascade that promotes fat oxidation, increases cellular stress defenses and autophagy, and decreases inflammation.
  
  For those who practice Intermittent Fasting as well as low carb or ketogenic diets, intermittent fasting and ketogenic diets are known to trigger autophagy
  
  Increasing AMPK activation and why you should care;

  Increased AMPK activation is associated with:

  • Reduction of blood triglycerides
  • Extended life span by as much as 20-30% in animals,
  • Inhibiting excess fat synthesis and increased burning of stored fat
  • Decreased liver fat accumulation and fat-related chronic inflammation
  • Improved glucose uptake in cells, lowering blood sugar
  • Increased numbers of new, healthy mitochondria

  Berberine
  
  Berberine is an alkaloid extracted from various plants used in traditional Chinese medicine. It's primarily used to reduce insulin resistance and improve biomarkers of type II diabetes such as fasting glucose and HbA1c. Berberine also enhances the action of the AMPK enzyme that we mentioned above.
  
  Berberine is one of the most well known compounds among the diabetic and low carb community. In a study comparing Berberine to the drug Metformin, Berberine significantly decreased HbA1c levels in diabetic patients. The effect of decreasing HbA1c was comparable to that of Metformin. In addition, berberine decreased serum triglyceride and total cholesterol significantly whereas Metformin did not. HDL-C and LDL-C levels of patients treated with berberine were also reduced. Insulin sensitivity was enhanced by berberine as the HOMA-IR value was reduced by nearly 50%.
  
  Berberine may also aid in fat loss because its effect on increasing insulin sensitivity may be related to fat distribution by berberine because waist and waist/hip of the patients in studies were decreased significantly in the absence of weight change. (6) (7) (8) (9).
  
  ** In June of 2023, people on social media and tv media started touting berberine as “nature’s Ozempic.” Ozempic (the generic drug name is Semaglutide), so we felt it was important to mention this in the description of Berberine.
  
  Ozempic, a drug used to treat diabetes, keeps gaining attention as celebrities, Elon Musk and TikTok influencers have admitted to taking it to lose weight and lose weight in a very short time frame. Ozempic and Semaglutide are part of a class of drugs called GLP-1 agonists, which mimic a hormone that helps reduce food intake and appetite.
  
  While both berberine and GLP-1 agonists like Ozempic and Wegovy, Tirzepatide (Mounjaro) have some effects on weight, they work through different mechanisms. GLP-1 agonists mimic the action of a hormone called glucagon-like peptide-1 (GLP-1), which helps reduce food intake and appetite through the augmentation of insulin secretion, suppression of glucagon secretion, and deceleration of gastric emptying.”
  
  Berberine is NOT like Ozempic. Berberine is not a drug nor does it come with the negative side effects of drugs.
  
  Berberine promotes weight loss through different pathways, such as AMPK activation and improvements in insulin sensitivity.
  
  A review of 12 studies in 2020 found that supplementing with berberine led to significant reductions in body weight, body mass index, and belly fat.
  
  Gynostemma Pentaphyllum Extract
  
  Gynostemma Pentaphyllum Extract also known as "Southern Ginseng" is one of the most exciting and interesting ingredientsin Glucosatrol that is only found in a few products currently on the market. Gynostemma Pentaphyllum is another powerful simulator of AMPK.
  

  Gynostemma Pentaphyllum has shown impressive abilities as an anti-obesity compound. In a trial of 80 healthy obese subjects, those taking a Gynostemma Pentaphyllum Extract lost on average 10.9% of unhealthy visceral fat, 6% of belly fat and 3.8% of fat under the skin (subcutaneous fat) in 3 months. (47) 

  
  Gynostemma Pentaphyllum also has impressive antidiabetic abilities. In a 12 week randomized study, subjects taking Gynostemma Pentaphyllum showed a 5-fold reduction in fasting glucose, a 10-fold reduction in hemoglobin A1c, a measure of chronic glucose exposure, and a near 3-fold decrease in insulin resistance. (48). Another study in 2012 studied 25 patients taking the pharmaceutical, gliclazide. The Gynostemma Pentaphyllum group had improvements in fasting plasma glucose, HbA1c, and oral glucose tolerance test outcomes compared to the placebo group.(49)
  
  Bitter Melon Extract
  
  Bitter Melon is a unique herb that is often praised in the low carb and diabetic community. Bitter melon is a vegetable used in India and other Asian countries. The fruit and seeds are used to make medicine. In a study it was shown that Bitter Melon Extract seems to be as effective as a very powerful anti-diabetic medication Tolbutamide. Bitter Mellon may reduce glycogen formation in the liver while boosting glucose utilization.[10-11].
  
  Research also shows that bitter melon can have beneficial effects on fat burning and weight loss. One study found that over a 7 week period, subjects taking bitter melon extract each day led to significant decreases in belly fat. The people in the study lost an average of 1/2 inch from their waist circumference after seven weeks. (12)

  Bitter melon also increases the activity of AMPK.

  Because of the elevated use of the AMPK, the body undergoes glucose shortages and the body uses fats instead of energy.
  
  Banaba Leaf Extract 
  
  Banaba has very powerful blood glucose levels lowering abilities by inhibition of carbohydrate digestion (13-14)
  
  Most products that use Banaba Leaf Extract are only standardized for 1-2% of Corosolic acid, Glucosatrol is standardized for a POTENT 10% Corsolic acid.
  
  Corosolic Acid is the key component in Banaba Leaf which is where all the benefits come from. Most products and studies only use 3mg-10mg of Corsolic Acid, Glucosatrol is standardized for a whopping 30mg!
  
  Researchers found that corosolic acid can safely lower blood glucose levels in Type II diabetics, or non-insulin dependent diabetics. Subjects who took a TINY DOSAGE of 0.48 mg of Corosolic Acid over a 22-week period had a huge 30 percent average drop in their blood glucose levels. Subjects also averaged a weight loss of 3.2 pounds a month. (15)
  
  Gymnema Sylvestre Extract
  
  Gymnema is a traditional herb used in India and has been used for medical purposes dating back 5,000 years. People commonly use Gymnema to help eliminate sugar cravings, balance blood sugar levels, regulate body weight, and lower insulin secretion. (16). Possibly the number one use of gymnema is its powerful ability to reduce sugar cravings. (17-18). Gymnema is also one of the most common ingredients found in a glucose disposal agent and has been for many years.
  
  Gymnema has also been shown to have anti-obesity effect in humans and rats, prevents weight gain and can improve health markers commonly found with being overweight or obese (19-20). An 8 week study in India in 60 moderately obese subjects showed that people found that they eat less when they take Gymnema before meals. Other results of the study showed that body weight and BMI decreased by 5-6%. Food intake, total cholesterol, low-density lipoproteins, triglycerides and serum leptin levels were significantly reduced, while high-density lipoprotein levels and excretion of urinary fat metabolites increased. (21)
  
  Alpha Lipoic Acid 
  
  Alpha Lipoic Acid is a potent antioxidant with a wide list of uses and potential benefits. ALA It is found in every cell, where it helps turn glucose into energy. ALA is a potent antioxidant, a liver detoxifier, reduces fasting blood sugar and appetite, while boosting overall energy expenditure! It is one of the most extensively studied ingredients in the Glucosatrol formula. (22-26).
  
  ALA also increases the activity of AMPK, increasing the breakdown of liver fat and reduce appetite. (53) This stimulation of AMPK in metabolic tissue reduces appetite and enhances liver fat breakdown. (54)
  

  
  Cinnamon Bark Extract

  In addition to being a great tasting spice, cinnamon has many benefits in the area of blood sugar regulation. Cinnamon has been shown to reduce blood glucose levels, burn body fat, and even enhance lean muscle mass. (28).
  
  Cinnamon has been shown to inhibit several digestive enzymes those of which are: alpha-glucosidase, sucrase, and pancreatic amylase. The inhibition of these enzymes decreases the amount of glucose that goes into systemic circulation and avoids insulin spikes. (29-30).
  
  Cinnamon has also been shown to improve insulin sensitivity and reduce blood glucose levels. Five studies with over 300 subjects done on cinnamon showed up to a 29% reduction in fasting blood glucose levels. (31-33).

  Cinnamon extract also increases the activity of AMPK.

  Because of the elevated use of the AMPK, the body undergoes glucose shortages and the body uses fats instead of energy.
  
  Olive Leaf Extract

  Olive Leaf Extract, or more so its active ingredient Olerurpoein is a common ingredient found in many thermogenic "fat burners" and glucose disposal supplements. Oleuropein has been shown to improve insulin sensitivity, protect against LDL cholesterol oxidation, and inhibit peroxisome proliferator-activated receptor gamma.[36,37]. PPAR inhibition has been shown to potentially inhibit new fat cell formation.
  
  Olive leaf extracts have also been shown to be potent thyroid hormone boosters. This increase in thyroid levels then leads to increased energy expenditure and may help combat obesity, diabetes, and metabolic disorder. (38). In ahead-to-head study done in diabetic rats comparing either olive leaf extract or glyburide (Diabeta(®)), a common glucose-lowering drug, it was shown that the antidiabetic effects of olive leaf extract proved superior to those of the drug.(39)

  Green Coffee Bean Extract

  Chlorogenic Acid (CGA) is a polyphenol compound in green coffee that is responsible for the all of green coffees health benefits. Green coffee bean extract is the primary natural source of chlorogenic acid. One of the primary benefits of CGA is its abality to inhibit the enzyme alpha-glucosidase, which is responsible for breaking down carbohydrates; essentially it reduces the uptake of carbohydrates and glucose during digestion (44)
  
  Green coffee bean extract has been shown to have anti-diabetic benefits. Studies have shown that consumption of 3 to 4 cups of decaffeinated coffee containing high contents of CGA significantly reduced the risk for T2DM by 30% (40). Chlorogenic acid (CGA) is considered an insulin sensitizer that potentiates insulins action similar to the therapeutic action of the diabetic drug Metformin (41). Clinical trials have also showed that CGA is able to lower the glycemic impact of foods and chronically lower blood glucose levels of Type 2 Diabetics (42). In animal models, CGA has been shown to suppress body weight gain and visceral fat accumulation. (43).

  Green Coffee Bean Extract also increases the activity of AMPK.

  Finally, Green Coffee Bean Extract also helps decrease gluconeogenesis, the process of turning non-carbohydrate foods, such as protein, into sugar. (46)
  
  
  Vanadyl sulfate

  Vanadyl Sulfate has been used for decades in the fitness and bodybuilding communities for its beneficial effects on blood glucose, carbohydrate metabolism and its ability to lower your resting blood sugar levels and HbA1c (50, 51). Vanadyl sulfate has been shown to create and protect pancreatic cells, hence the insulin-like effects (52)
  
  In layman's terms, Vanadyl Sulfate should help ease some negatives of excess carbohydrate intake. It can help dietary carbohydrates stay away from fat cells, which will keep your waistline nice and trim! and send your carbs to your muscle instead. (50). Glucose being used for glycogen stores should also mean better performance, especially during a hard dieting phase.
  
  Vitamin B6
  
  Vitamin B6 was included for its role in the metabolism of carbohydrates, fats and proteins, and helps release glycogen (used in energy production) from the liver and muscles.
  
  BioPerine®
  
  Bioperine is a patented extract obtained from black pepper fruits (Piper nigrum) standardized minimum to 95% Piperine. BioPerine has been used as a bioavailability enhancer for over 20 years. In general, BioPerine was found to enhance absorption of nutrients by at least 30%. It was included in the Glucosatrol formula to enhance bioavailability of all the already powerful ingredients!

• WARNINGS

  For those who take medicine for diabetes and blood sugar control, please consult with your doctor before taking any sort of glucose disposal agent.
  
  †These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease

• REFERENCES

  
  
  (1) - https://www.ncbi.nlm.nih.gov/pubmed/23683609
  (1a)- https://www.ncbi.nlm.nih.gov/pubmed/15208835
  (2) - https://www.ncbi.nlm.nih.gov/pubmed/24523404
  (3) - https://link.springer.com/content/pdf/10.1007%2Fs00125-005-1698-2.pdf
  (4) - https://onlinelibrary.wiley.com/doi/pdf/10.1002/mus.20286
  (5) - https://mdanderson.elsevierpure.com/en/publications/plasma-glucose-lowering-effect-of-%CE%B2-endorphin-in-streptozotocin-i
  (6) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/
  (7) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/#R9
  (8) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/#R10
  (9) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2410097/#R8
  (10) - https://www.sciencedirect.com/science/article/pii/S1383586606002966
  (11) - Cousens G. There is a cure for diabetes: the tree of life 21 day program. California: North Atlantic Books; 2008. pp. 191–192
  (12) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311063/
  (13) - https://www.ncbi.nlm.nih.gov/pubmed/16549220
  (14) - https://www.ncbi.nlm.nih.gov/pubmed/12787964
  (15) - https://www.sciencedirect.com/science/article/pii/S0378874103001223
  (16) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170951/
  (17) - https://www.ncbi.nlm.nih.gov/pubmed/29905783
  (18) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2170951/
  (19) - https://www.ncbi.nlm.nih.gov/pubmed/28514906
  (20) - https://www.ncbi.nlm.nih.gov/pubmed/23842942
  (21) - https://www.ncbi.nlm.nih.gov/pubmed/15056124
  (22) - https://www.ncbi.nlm.nih.gov/pubmed/21666939
  (23) - https://www.ncbi.nlm.nih.gov/pubmed/15195087
  (24) - https://www.ncbi.nlm.nih.gov/pubmed/21505371
  (25) - https://www.ncbi.nlm.nih.gov/pubmed/20015518
  (26) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5583617/
  (27) - https://www.sciencedirect.com/science/article/pii/0928098795000453?via%3Dihub
  (28) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2129164/
  (29) - https://www.ncbi.nlm.nih.gov/pubmed/21711570
  (30) - https://www.ncbi.nlm.nih.gov/pubmed/21538147
  (31) - https://www.ncbi.nlm.nih.gov/pubmed/10725162
  (32) - https://www.ncbi.nlm.nih.gov/pubmed/19930003
  (33) - https://www.ncbi.nlm.nih.gov/pubmed/17381386
  (34) - https://doi.org/10.1007/s11655-007-9005-3
  (35) - https://nutritionj.biomedcentral.com/articles/10.1186/1475-2891-13-7
  (36) - http://www.ncbi.nlm.nih.gov/pubmed/23516412
  (37) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3896615/
  (38) - https://www.ncbi.nlm.nih.gov/pubmed/12164280
  (39) - https://www.ncbi.nlm.nih.gov/pubmed/18844257
  (40) - https://www.ncbi.nlm.nih.gov/pubmed/20008687
  (41) - https://www.ncbi.nlm.nih.gov/pubmed/15694706
  (42) - https://www.ncbi.nlm.nih.gov/pubmed/23444965
  (43) - https://www.ncbi.nlm.nih.gov/pubmed/16545124
  (44) - https://www.ncbi.nlm.nih.gov/pubmed/20522017
  (45) - https://www.ncbi.nlm.nih.gov/pubmed/9056264
  (46) - https://www.ncbi.nlm.nih.gov/pubmed/9056264
  (47) - https://www.ncbi.nlm.nih.gov/pubmed/23804546
  (48) - https://www.ncbi.nlm.nih.gov/pubmed/20213586
  (49) - https://www.ncbi.nlm.nih.gov/pubmed/23125867
  (50) - https://www.ncbi.nlm.nih.gov/pubmed/7769096
  (51) - https://academic.oup.com/jcem/article/86/3/1410/2847866
  (52) - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4156977/
  (53) - https://www.ncbi.nlm.nih.gov/pubmed/15195087
  (54) - https://pubmed.ncbi.nlm.nih.gov/11602326/